During the regulated era of US aviation the realm of long-haul international flights was restricted to Pan Am, TWA, Braniff and Northwest each with their own spheres. Then out of nowhere National won the award to serve Heathrow from Miami:
National Airlines Douglas DC-8 & Boeing 747-100 by rstretton, on Flickr
National Airlines Douglas DC-8 & Boeing 747-100 by rstretton, on Flickr